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Cannabidiolic acid (CBDA) and cannabigerolic acid (CBGA) are lesser-known compounds found within the raw cannabis sativa plant, both of which may have exciting effects on the world of health and wellness based on early-stage recent research. In fact, some experts consider these compounds the next frontier when it comes to cannabinoid-based therapy—expanding the potential development of medications that are not only more therapeutically effective, but also less likely to cause unwanted side effects and/or long-term dependency than current options.
CBGA is a foundational compound of the raw cannabis flower, formed in the cannabis plant when geranyl pyrophosphate and olivetolic acid combine. The resulting enzymatic reaction converts CBGA into several different cannabinoids, leading to its sometimes being called the mother cannabinoid. In fact, CBGA is the precursor to three of the most commonly found cannabinoids: tetrahydrocannabinolic acid (THCA), cannabichromenic acid (CBCA) and CBDA. These are known as acidic cannabinoids. CBGA (Cannabigerolic acid) holds potential for treating diseases, but more data is needed to support anecdotal claims to suggest CBGA as a treatment option. Some data indicates that CBGA may make the body more receptive to other cannabinoids, plus assisting the body as it processes them. CBGA also has some reported analgesic, anti-inflammatory, antibacterial and anti-proliferative properties.
In most cannabis plants, cannabidiolic acid appears in only small amounts, though hemp oil, in particular, is known for its higher CBDA content. And because it is non-intoxicating, CBDA is completely legal in nearly every state. Additionally, cannabidiolic acid has greater bioavailability; meaning it is absorbed by the body up to 11 times better than CBD when taken orally. There is also some animal-based data that CBDA is, in fact, stronger and more potent than CBD. This appears to be not just because CBDA is absorbed better, but because it actually acts more effectively in the body to address symptoms like nausea and vomiting, pain, inflammation and even seizures.